Memory enhancement by multidomain group cognitive training in patients with Parkinson’s disease and mild cognitive impairment: long-term effects of a multicenter randomized controlled trial

• DOI: 10.1007/s00415-021-10568-9
• Publication Date: 2021-04-27T08:02:17Z
• Authors: Nele Schmidt; Inken Tödt; Daniela Berg; Christian Schlens...; Ann-Kristin Folkerts; Anja Ophey; Karina Dimenshteyn; Saskia Elben; Lars Wojtecki; Inga Liepelt-Scar...; Claudia Schulte; Patricia Sulzer; Carsten Eggers; Elke Kalbe; Karsten Witt
• Keywords: Neuroradiology; Post-hoc analysis; Cognitive Training

Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT PD mild impairment (PD-MCI). Immediately after CT, an enhancement executive functions demonstrated. Here, we present the results 6 12 months CT.At baseline, 64 PD-MCI were multidomain group (n = 33) or low-intensity physical activity control (PT) 31). Both interventions included 90 min sessions twice week for weeks. 54 completed (CT: n 28, PT: 26) 49 follow-up assessment 25, 24). Primary study outcomes memory functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests multiple regression analyses conducted.We found significant time x interaction effect score (p 0.006, η2 0.214), but 0.967, 0.002). Post-hoc revealed verbal nonverbal improvements from pre-intervention months, group. No predictors predicting improvement CT.This provides Class 1 evidence that enhances whereas change long-term.German Clinical Trials Register (ID: DRKS00010186), 21.3.2016 (The registration is outlined as retrospective due administrative delay. The first patient enrolled three process started. A formal confirmation this German can be obtained authors.).