Time to onset and duration of botulinum toxin efficacy in movement disorders

• DOI: 10.1007/s00415-022-10995-2
• Publication Date: 2022-02-03T10:03:10Z
• Authors: Claudia Ledda; Carlo Alberto Artusi; Antonella Tribolo; Domiziana Rinaldi; Gabriele Imbalzano; Leonardo Lopiano; Maurizio Zibetti
• Keywords: Cervical dystonia; Clinical efficacy; Blepharospasm; Movement Disorders

Botulinum toxin (BoNT) is a valuable treatment in movement disorders; however, time to onset and duration of efficacy may widely differ among patients. We aimed clarify the impact main demographic clinical features on BoNT efficacy.We analyzed time-to-onset 186 consecutive patients treated with for blepharospasm, cervical dystonia, facial hemispasm, oromandibular limb sialorrhea due Parkinsonism. The following factors were considered as potential predictors: doses types toxin, sex, age, years treatment, condition. Kruskall-Wallis, Spearman correlation, multivariate linear regression used statistical analysis.The average was 6.7 ± 5 days BONT 78.5 28.4 days. Both correlated (p: 0.007 p: 0.02). multiple analysis showed that doses, type condition significantly predicted (F(11, 171) = 2.146, 0.020) age being strongest predictor 0.004). same model explained 20.1% variance efficacy, showing significant prediction outcome 164) 3.754, p < 0.001), (p 0.017), 0.001) predictors.Our findings suggest especially account variability terms duration.