The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes

• DOI: 10.1007/s00415-022-11402-6
• Publication Date: 2022-10-15T05:02:29Z
• Authors: Mark Thaller; Victoria Homer; Yousef Hyder; Andreas Yiangou; Anthony Liczkowski; Anthony W. Fong; Jasvir Virdee; Rachel Piccus; Marianne Roque; Susan P. Mollan; Alexandra J. Sinc...
• Keywords: Neuroradiology

There are limited longitudinal data evaluating outcomes in idiopathic intracranial hypertension (IIH). We aimed to evaluate the long-term a real-world cohort of patients with IIH and sought establish prognostic factors.A prospective study was conducted over 9 years (2012-2021). Data included demographics disease status. All consenting were recruited. Visual visual acuity, Humphrey field optical coherence tomography (OCT) imaging measurements. Headache frequency, severity, impact noted. analysed key variables impacting headache outcomes.The contained 490 confirmed diagnosis. 98% female mean body mass index (BMI) 38 kg/m2. Those highest OCT retinal nerve fibre layer had worst outcomes. noted delayed decline, ganglion cell after 12 months. In medically managed (n = 426), we found that duration change BMI greatest influence on high burden headache, daily at presentation prior migraine history influencing prognosis.There is decline those most severe papilloedema. Disease factors, therefore more acute may require closer monitoring. Improving prognosis should focus potentially modifiable factor weight management.