Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease

• DOI: 10.1007/s00415-023-11911-y
• Publication Date: 2023-08-04T04:01:58Z
• Authors: Marta Bellofatto; Luca Gentile; Alessandro Bertini; Irene Tramacere; Fiore Manganelli; Gian Maria Fabrizi; Angelo Schenone; Lucio Santoro; Tiziana Cavallaro; Marina Grandis; Stefano C. Previtali; Marina Scarlato; Isabella Allegri; Luca Padua; Costanza Pazzaglia; Flavio Villani; Eleonora Cavalca; Paola Saveri; Aldo Quattrone; Paola Valentino; Stefano Tozza; Massimo Russo; Anna Mazzeo; Giuseppe Vita; Sylvie Piacentini; Giuseppe Didato; Chiara Pisciotta; Davide Pareyson; ; Giulia Schirinzi; Maria Montesano; Sara Nuzzo; Francesca Oggiano; Daniela Calabrese; Chiara Gemelli; Yuri Falzone; Emanuele Spina; Maria Longo; Giuseppe Occhipinti; Giacomo Iabichella; Stefania Barone
• Keywords: Epworth Sleepiness Scale; Somnolence; Depression; Restless Legs Syndrome

Sleep abnormalities have been reported in Charcot-Marie-Tooth disease (CMT), but data are scanty. We investigated their presence and correlation a large CMT patients' series.Epworth Sleepiness Scale (ESS) Pittsburgh Quality Index (PSQI) were administered to patients of the Italian registry controls. ESS score > 10 indicated abnormal daytime somnolence, PSQI 5 bad sleep quality. analyzed with severity characteristics, Hospital Anxiety Depression (HADS), Modified Fatigue Impact (MFIS), Body Mass Index, drug use.ESS questionnaires filled by 257 253 patients, respectively, 58 Median was higher than controls (6 vs 4, p = 0.006), no difference for score. Abnormal somnolence poor quality occurred 23% 56% patients; such had more frequently anxiety/depression, fatigue, positive sensory symptoms those normal ESS/PSQI. Moreover, severe (median Examination Score, CMTES, 8 6, 0.006) frequent use anxiolytic/antidepressant drugs (29% 7%, < 0.001).Bad sleepiness correlated anxiety, depression confirming that different components affect sleep. disorders, as apnea restless leg syndrome, not specifically here, other factors known impact on somnolence. management must include behavior assessment evaluation its factors, including general distress fatigue.