Different pain phenotypes are associated with anti-Caspr2 autoantibodies

• DOI: 10.1007/s00415-024-12224-4
• Publication Date: 2024-02-22T13:05:36Z
• Authors: Patrik Greguletz; Maria Plötz; Carolin Baade-Büt...; Christian G. Bien; Katharina Eisenhut; Christian Geis; Robert Handreka; Jaqueline Klausewitz; Peter Körtvelyessy; Stjepana Kovac; Andrea Kraft; Jan Lewerenz; Michael Malter; Michael Nagel; Felix von Podewils; Harald Prüß; Anna Rada; Johanna Rau; Sebastian Rauer; Rosa Rößling; Thomas Seifert-Held; Kai Siebenbrodt; Kurt-Wolfram Sühs; Simone C. Tauber; Franziska Thaler; Judith Wagner; Jonathan Wickel; Frank Leypoldt; Heike L. Rittner; Claudia Sommer; Carmen Villmann; Kathrin Doppler; ; Michael Adelmann; Luise Appeltshauser; Ilya Ayzenberg; Andreas van Baalen; Sebastian Baatz; Oliver Bähr; Bettina Balint; Sebastian Bauer; Annette Baumgartner; Stefanie Becker; Sonka Benesch; Robert Berger; Birgit Berger; Martin Berghoff; Sascha Berning; Sarah Bernsen; Achim Berthele; Christian Bien; Corinna Bien; Andreas Binder; Stefan Bittner; Daniel Bittner; Franz Blaes; Astrid Blaschek; Amelie Bohn; Sergio Castro-Gomez; Justina Dargvainiene; Timo Deba; Julia Maren Decker; Andre Dik; Juliane Dominik; Mona Dreesmann; Friedrich Ebinger; Lena Edelhoff; Laura Ehrhardt; Sven Ehrlich; Alexander Emmer; Dominique Endres; Marina Entscheva; Daniela Esser; Thorleif Etgen; Jürgen Hartmut Faiss; Kim Kristin Falk; Walid Fazeli; Alexander Finke; Carsten Finke; Dirk Fitzner; Marina Flotats-Ba...; Mathias Fousse; Tobias Freilinger; Paul Friedemann; Manuel Friese; Marco Gallus; Marcel Gebhard; Anna Gorsler; Armin Grau; Oliver Grauer; Britta Greshake; Catharina Groß; Thomas Grüter; Aiden Haghikia; Niels Hansen; Jens Harmel; Antonia Harms; Yetzenia Dubraska...; Martin Häusler; Joachim Havla; Chung Ha-Yeun; Wolfgang Heide; Valentin Held; Kerstin Hellwig; Philip Hillebrand; Frank Hoffmann; Christian Hofmann; Ulrich Hofstadt-v...; Peter Huppke; Hagen Huttner; Fatme Seval Ismail; Martina Jansen; Mareike Jansen; Aleksandra Juranek; Michael Karenfort; Max Kaufmann; Christoph Kelling...; Constanze Kerin; Susanne Knake; Ellen Knierim; Peter Körtvélyessy; Markus Krämer; Verena Kraus; Christos Krogias; Gregor Kuhlenbäumer; Tanja Kümpfel; Christoph Lehrich; Andeas Linsa; Jan Lünemann; Marie Madlener; Niels Margraf; Carlos Martinez Q...; Monika Meister; Nico Melzer; Kristin Stefanie ...; Til Menge; Sven Meuth; Gerd Meyer zu Hörste; Fabian Möller; Marie-Luise Mono; Sigrid Mues; Jost Obrocki; Loana Penner; Lena Kristina Pfe...; Thomas Pfefferkorn; Steffen Pfeuffer; Alexandra Philipsen; Johannes Piepgras; Felix von Poderwils; Mosche Pompsch; Josef Priller; Anne-Katrin Pröbstel; Daniel Rapp; Dominica Ratuszny; Johanna Maria Hel...; Saskia Jania Räuber; Robert Rehmann; Ina Reichen; Gernot Reimann; Raphael Reinecke; Nele Retzlaff; Marius Ringelstein; Henrik Rohner; Felix Rosenow; Kevin Rostasy; Theodor Rüber; Stephan Rüegg; Yannic Saathoff; Jens Schaumberg; Ruth Schilling; Mareike Schimmel; Jens Schmidt; Ina-Isabelle Schmütz; Hauke Schneider; Patrick Schramm; Stephan Schreiber; Gesa Schreyer; Ina Schröder; Simon Schuster; Günter Seidel; Frank Seifert; Makbule Senel; Olga Simova; Juliane Spiegler; Oliver Stammel; Andeas Steinbrecher; Henning Stolze; Muriel Stoppe; Karin van`s Grave...; Christine Strippel; Dietrich Sturm; Klarissa Hanja St...; Steffen Syrbe; Pawel Tacik; Simone Tauber; Florian Then Bergh; Anja Tietz; Corinna Trebst; George Trendelenburg; Regina Trollmann; Thanos Tsaktanis; Hayrettin Tumani; Methap Türedi; Christian Urbanek; Niklas Vogel; Max Vogtmann; Matthias von Mering; Jan Wagner; Klaus-Peter Wandi...; Robert Weissert; Brigitte Wildemann; Karsten Witt; Kartharina Wurdack; Lara Zieger
• Keywords: myalgia; Limbic Encephalitis; Autoimmune encephalitis; Neuromyotonia

Abstract Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on in a large cohort of patients included into the German Network for Research Autoimmune Encephalitis. Out 102 our cohort, was frequent symptom (36% all patients), often severe (63.6% pain) and/or even major (55.6% pain). Pain phenotypes differed between patients. Cluster analysis revealed two including mostly distal-symmetric burning and widespread myalgia cramps. Almost had IgG4 autoantibodies some additional IgG1, 2, 3 autoantibodies, IgG subclasses, titers, presence or absence intrathecal synthesis were occurrence pain. However, certain pre-existing risk factors chronic like diabetes mellitus, peripheral neuropathy, preexisting back tended to occur more frequently anti-Caspr2 Our show that is relevant support idea decreased algesic thresholds leading Testing needs be considered various phenotypes.