Optical coherence tomography angiography in pre-perimetric open-angle glaucoma

• DOI: 10.1007/s00417-017-3709-7
• Publication Date: 2017-06-19T06:23:00Z
• Authors: Gilda Cennamo; Daniela Montorio; Nunzio Velotti; Federica Sparnelli; Michele Reibaldi; Giovanni Cennamo
• Keywords: SD-OCT; Male; Retinal Ganglion Cells; OCT angiography; Open-angle glaucoma; SD-OCT; Visual field; Aged; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Nerve Fibers; Optic Disk; Prospective Studies; ROC Curve; Retinal Ganglion Cells; Tomography, Optical Coherence; Visual Field Tests; Visual Fields; Early Diagnosis; Fundus Oculi; Optic Disk; OCT angiography; Open-angle glaucoma; SD-OCT; Visual field; Aged; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Glaucoma; Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Nerve Fibers; Optic Disk; Prospective Studies; ROC Curve; Retinal Ganglion Cells; Tomography; Optical Coherence; Visual Field Tests; Visual Fields; Early Diagnosis; Cellular and Molecular Neuroscience; 03 medical and health sciences; Nerve Fibers; 0302 clinical medicine; Humans; Prospective Studies; Fluorescein Angiography; Open-angle glaucoma; Intraocular Pressure; Aged; OCT angiography; OCT angiography; Open-angle glaucoma; SD-OCT; Visual field; Ophthalmology; Sensory Systems; Cellular and Molecular Neuroscience; Middle Aged; Visual field; Sensory Systems; Ophthalmology; Early Diagnosis; ROC Curve; Visual Field Tests; Female; Visual Fields; Glaucoma, Open-Angle; Tomography, Optical Coherence; Follow-Up Studies

To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma.Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated. Receiver operating characteristic curves for OCT angiography parameters were assessed.The flow index (p = 0.021) and vessel density (p = 0.001) were significantly lower in pre-perimetric glaucoma eyes versus normal eyes. Ganglion cell complex parameters were significantly correlated to OCT angiography parameters (p < 0.05). Neither retinal nerve fiber layer (RNFL) nor visual field parameters correlated with OCT angiography parameters.OCT angiography can be considered a reliable, easy-to-perform method with which to evaluate microvascular changes of optic nerve head for the early diagnosis and follow-up of glaucoma.