Lung cancer risk in workers occupationally exposed to polycyclic aromatic hydrocarbons with emphasis on the role of DNA repair gene

• DOI: 10.1007/s00420-022-01926-9
• Publication Date: 2022-10-26T13:07:41Z
• Authors: Gehan Moubarz; Amal Saad-Hussein; Eman M. Shahy; Heba Mahdy-Abdallah; Atef M. F. Mohammed; Inas A. Saleh; Mona A. M. Abo-Zeid; Mahmoud T. Abo-El...
• Keywords: DNA adduct; Nonsense mutation

Workers in secondary aluminum production plants are occupationally exposed to polycyclic aromatic hydrocarbons (PAHs). We aimed monitor the concentrations of PAHs air and serum workers at two plants. also investigated potential risk lung cancer development among with emphasis on role A1AT mutation APEX1 gene polymorphisms.This study included 177 from administrative departments lines. Blood samples were obtained for estimation benzo(a)pyrene diol epoxide albumin adduct (BPDE-Alb adduct), anti-Cyclin-B1 marker (CCNB1) squamous cell carcinoma antigen (SCCAg). Genes' polymorphism human apurinic/apyrimidinic endonuclease (APEX1) alpha-1-anti-trypsin (A1AT) detected.There was a significant increase level BPDE-Alb comparison non-exposed group. Moreover, 41.67% El Tebbin had ≥ 15 ng/ml versus 29.6% Helwan factory. There tumor markers (SCCAg CCNB1) whose ng/ml. adducts carrying homozygous genotype Glu/Glu. Furthermore, Glu/Glu high levels. levels mutant allele. significantly levels.Therefore, we conclude that may be due exposure. Although within permissible limits, yet evidence DNA damage present as expressed by BPDE-albumin workers. Also, elevation points importance periodic biological monitoring such protect them risk.