Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients

• DOI: 10.1007/s00421-010-1362-5
• Publication Date: 2010-02-03T07:14:46Z
• Authors: Dominique Hansen; Paul Dendale; Milou Beelen; Richard A. M. Jon...; Annelies Mullens; Luk Corluy; Romain Meeusen; Luc J. C. van Loon
• Keywords: Resistin

Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal FFA, between non-obese patients healthy, controls. A total 20 normoglycemic males (BMI <30 kg/m2), kg/m2) >35 were selected participate study. Groups matched for age habitual physical activity level. Body composition, glycemic control, exercise performance capacity assessed. Basal blood samples collected determine leptin, adiponectin, resistin, tumor necrosis factor α (TNFα), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) FFA concentrations. Plasma marker (hsCRP, IL-6, TNFα), (adiponectin, leptin), triglyceride did not differ hsCRP, levels significantly higher when compared with healthy controls (P < 0.05). Furthermore, hsCRP leptin versus Significant correlations parameters control observed, but disappeared after adjusting trunk adipose tissue mass. associated obesity necessarily state.