Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

• DOI: 10.1007/s00421-021-04635-2
• Publication Date: 2021-03-16T01:04:34Z
• Authors: Zerbu Yasar; Bradley T. Elliott; Yvoni Kyriakidou; Chiazor T. Nwokoma; Ruth D. Postlethw...; Christopher J. Ga...; Susan Dewhurst; Lawrence D. Hayes
• Keywords: Sprint; Interval training; Monocyte

The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines growth factors. A secondary aim was whether a novel sprint interval training (SIT) intervention (3 × 20 s 'all out' static sprints, twice week for 8 weeks) would affect inflammatory markers in older men.Nine men [68 (1) years] eleven younger [28 (2) comprised group. Aerobic fitness were taken at baseline both groups following SIT group.Interleukin (IL)-8, vascular endothelial factor (VEGF), monocyte chemoattractant protein-1 (MCP-1) unchanged (IL-8, p = 0.819; MCP-1, 0.248; VEGF, 0.264). Epidermal (EGF) greater group compared [142 (20) pg mL-1 60 (12) mL-1, respectively, 0.001, Cohen's d 1.64]. Following SIT, decreased EGF 100 which similar that young who did not undergo (p 0.113, 1.07).Older aerobically trained have serum than men. can shift towards concentrations. As lower has previously been associated with longevity C. elegans, manipulative healthy ageing human may be further interest.