Pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma: additional evidence to support they are a single disease with variation in the histologic spectrum

• DOI: 10.1007/s00428-024-03941-2
• Publication Date: 2024-10-08T17:02:11Z
• Authors: Huan-Ge Li; Xiang-Nan Jiang; Tian Xue; Bei-Bei Xin; Lian Chen; Gui-Xin Li; Qian Wang; Qin-Qin Hou; Xu Cai; Xiao-Yan Zhou; Xiao-Qiu Li
• Keywords: Follicular lymphoma; Variation (astronomy)

Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone (PNMZL) are two rare indolent B-cell lymphomas with overlapping features. Recently, cases showing hybridizing features of PTFL PNMZL have been reported. Herein, we retrospectively analyzed the clinicopathologic 59 patients, including 39 PTFL, 5 PNMZL, 15 mixed-type tumors (MTT). And next-generation sequencing analysis was performed on 3 2 MTT cases. In addition, previously published mutational data 96 PTFLs, 25 PNMZLs, 46 MTTs were also analyzed. There 52 male 7 female a median age 17 years. Most patients (96.6%) had lymph node involvement in head neck region diagnosed stage I disease. Among 50 (85%) telephone follow-up, 44 (88%) adopted watch-and-wait strategy after surgical resection lesions. Only one patient experienced relapse 6 months diagnosis. Microscopically, not only showed composite form enlarged follicles interfollicular lymphocytic proliferation producing progressively transformed germinal center (PTGC) pattern, but focal PTGC-like pattern observed Genetically, most frequently mutated genes TNFRSF14 (in PTFLs MTTs), MAP2K1 1 MTT), IRF8 PNMZL). Based similar or clinical, pathologic, genetic features, likely to represent different histologic patterns same