Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra

• DOI: 10.1007/s00429-012-0402-9
• Publication Date: 2012-03-10T01:11:25Z
• Authors: Pablo Garrido-Gil; Rita Valenzuela; Begoña Villar-Cheda; Jose L. Lanciego; Jose L. Labandeir...
• Keywords: Pars compacta

We have previously obtained in rodents a considerable amount of data suggesting major role for the brain renin-angiotensin system (RAS) dopaminergic neuron degeneration and potentially Parkinson's disease. However, presence local RAS has not been demonstrated monkey or human substantia nigra compacta (SNc). The present study demonstrates components neurons, astrocytes microglia both SNc. Angiotensin type 1 2 renin-prorenin receptors were located at surface neurons glial cells, as expected tissular RAS. angiotensinogen angiotensin also observed cytoplasm nuclear level, which suggests an intracrine intracellular Although labeled prorenin normal SNc, most cells appeared less immunoreactive than neurons. our previous studies rodent models PD other animal diseases suggest that activity is significantly upregulated pathological conditions. results together with findings nigral functioning progression degeneration.