Brain structural and functional correlates of the heterogenous progression of mixed transcortical aphasia

• DOI: 10.1007/s00429-023-02655-6
• Publication Date: 2023-05-31T10:03:15Z
• Authors: Diana López-Barroso; José Paredes-Pacheco; María José Torres...; Guadalupe Dávila; Marcelo L. Berthier
• Keywords: Disconnection

Mixed transcortical aphasia (MTCA) is characterized by non-fluent speech and comprehension deficits coexisting with preserved repetition. MTCA may evolve to less severe variants of aphasias or even full language recovery. Mechanistically, MCTA has traditionally been attributed a disconnection between the spared left perisylvian network (PSLN) responsible for verbal repetition, damaged extrasylvian networks, which are production impairments. However, despite significant advances in vivo neuroimaging, structural functional status PSLN its evolution not investigated. Thus, aim present study examine PSLN, both terms activity integrity, four cases who developed acute post-stroke progressed different types aphasia. For it, we conducted neuroimaging-behavioral performed chronic stage patients. The behavioral profile persisted one patient, whereas other three patients aphasias. Neuroimaging findings suggest that repetition does always depend on optimal dorsal connections. Instead, right hemisphere ventral pathway also play role supporting variability clinical be explained varying degree alteration individual premorbid neuroanatomical substrates. This offers fresh perspective through lens modern neuroscience unveils novel insights into neural underpinnings