Vitamin E supplementation improves neutropenia and reduces the frequency of infections in patients with glycogen storage disease type 1b

• DOI: 10.1007/s00431-008-0889-5
• Publication Date: 2008-12-08T09:43:45Z
• Authors: D. Melis; R. Della Casa; R. Parini; M. Rigoldi; C. Cacciapuoti; P. Marcolongo; A. Benedetti; V. Gaudieri; G. Andria; G. Parenti
• Keywords: Adult; Male; Neutropenia; Adolescent; Monosaccharide Transport Proteins; IBD; DNA Mutational Analysis; 610; Glycogen storage disease type 1b; Vitamin E; Severity of infections; G-CSF; IBD; G-CSF; Glycogen Storage Disease Type I; Antiporters; Young Adult; 03 medical and health sciences; Humans; Point Mutation; Vitamin E; Prospective Studies; Child; 0303 health sciences; Severity of infection; Bacterial Infections; 3. Good health; Treatment Outcome; Child, Preschool; Female; Glycogen storage disease type 1b

Neutropenia and/or neutrophil dysfunction are part of glycogen storage disease type 1b (GSD1b) phenotype. Recent studies indicated that activation of apoptosis and increased reactive oxygen species are implicated in the pathogenesis of neutropenia in GSD1b.We studied seven GSD1b patients over a 2-year-period to evaluate the efficacy of vitamin E, a known antioxidant, in preventing or improving the clinical manifestations associated with neutropenia and neutrophil dysfunction. Frequency and severity of infections, neutrophil counts and function, ileocolonoscopy and intestinal histology, were monitored. During the first year, patients did not assume vitamin E; during the second year of the study, vitamin E supplementation was added to their therapeutic regimens.During vitamin E supplementation, the mean values of neutrophil counts were significantly higher (p < 0.05) and neutrophil counts lower than 500/mm(3) were found less frequently (p < 0.05); the frequency and severity of infections, mouth ulcers and perianal lesions, was reduced (p < 0.05); ileocolonoscopy and histology showed a mild improvement. Vitamin E supplementation did not result in changes in neutrophil function.These results suggest that vitamin E supplementation might be beneficial in GSD1b patients and may alleviate disease manifestations associated with neutropenia.