Long-term outcomes of children with neonatal transfer: the Japan Environment and Children’s Study

• DOI: 10.1007/s00431-022-04450-7
• Publication Date: 2022-03-25T09:03:02Z
• Authors: Katsuya Hirata; Kimiko Ueda; Kazuko Wada; Satoyo Ikehara; Kanami Tanigawa; Tadashi Kimura; Keiichi Ozono; Hiroyasu Iso; ; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Masayuki Shima; Hiroshige Nakamura; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
• Keywords: Gross motor skill

Abstract This study aimed to evaluate the association of neonatal transfer with risk neurodevelopmental outcomes at 3 years age. Data were obtained from Japan Environment and Children’s Study. A general population 103,060 pregnancies 104,062 fetuses was enrolled in 15 Regional Centers between January 2011 March 2014. Live-born singletons various gestational ages, including term infants, without congenital anomalies who followed up until included. Neurodevelopmental impairment assessed using Ages Stages Questionnaire, third edition (ASQ-3) Logistic regression used estimate adjusted 95% confidence interval (CI) for newborns transfer. Socioeconomic perinatal factors included as potential confounders analysis. Among 83,855 live-born anomalies, 65,710 children studied. them, 2780 (4.2%) transferred period. After adjustment confounders, incidence (scores below cut-off value all 5 domains ASQ-3) higher compared those (communication: 6.5% vs 3.5%, OR 1.42, CI 1.19–1.70; gross motor: 7.6% 4.0%, 1.26, 1.07–1.49; fine 11.3% 7.1%, 1.19, 1.03–1.36; problem solving: 10.8% 6.8%, 1.29, 1.12–1.48; personal-social: 6.2% 2.9%, 1.52, 1.26–1.83). Conclusion : Neonatal associated a What is Known: • after birth preterm infants adverse short-term outcomes. Long-term outborn remain unclear. New: suggests that an increased impairment. Efforts referring high-risk pregnant women level centers may reduce transfer, leading improved neurological population.