Immunomodulatory effects of carbon ion radiotherapy in patients with localized prostate cancer

• DOI: 10.1007/s00432-022-04194-9
• Publication Date: 2022-09-23T03:30:46Z
• Authors: Wei Hu; Yulei Pei; Renli Ning; Ping Li; Zhenshan Zhang; Zhengshan Hong; Cihang Bao; Xiaomao Guo; Yun Sun; Qing Zhang
• Keywords: Radioresistance

Radiotherapy is one of the main local treatment modalities for prostate cancer, while immunosuppressive effect induced by radiotherapy an important factor radiation resistance and failure. Carbon ion (CIRT) a novel technique immunomodulatory CIRT provides possibility overcoming radioresistance improving efficacy. The aim this study was to assess immune response evoked in localized cancer patients.Thirty-two patients were treated combined with or without hormone therapy peripheral blood samples collected before after CIRT. Investigation cell frequency, proliferation, cytokine expression conducted flow cytometry, real-time quantitative PCR ELISA.There no significant differences frequencies CD3 + , CD4 CD8 T cells NK CD4/CD8 ratio increased whereas B decreased. All lymphocyte subsets except regulatory (Tregs) displayed proliferation exhibited functionality CIRT, characterized modestly secretion TNF. Moreover, higher Tregs shown. Neither monocytic myeloid-derived suppressor (MDSCs) nor early MDSCs changed TGF-β1 gene decreased IL-6 showed non-significant trend towards decrease. Both IL-10 plasma level unchanged.CIRT demonstrates potential elicit activation patients, based on sparing lymphocytes, enhanced T-cell functionality, together limited induction reduced cytokines.