Association between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study

• DOI: 10.1007/s00432-023-04755-6
• Publication Date: 2023-04-27T18:12:19Z
• Authors: Mauro De Santi; Giosuè Annibalini; Giuseppe Marano; Giacomo Biganzoli; Elisabetta Ventur...; Massimo Pellegrini; Francesco Lucertini; Giorgio Brandi; Elia Biganzoli; Elena Barbieri; Anna Villarini
• Keywords: Metabolic Syndrome; Breast cancer survivors; IGF-1; Metabolic syndrome; Tertiary cancer prevention; Research; Cholesterol, HDL; Breast cancer survivors; Breast Neoplasms; Metabolic syndrome; Tertiary cancer prevention; 3. Good health; Cancer Survivors; IGF-1; Humans; Female; Survivors; Insulin Resistance; Insulin-Like Growth Factor I; Aged

Circulating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and more frequently dysregulated in older people, especially those metabolic syndrome (MetS) obesity. This study aimed to analyze association between IGF-1 levels indices MetS insulin resistance survivors.Baseline data 563 survivors enrolled DIet ANdrogen-5 (DIANA-5; NCT05019989) were analyzed.Lower circulating subjects than without found. After stratification patients according diagnosis MetS, we highlighted that was main predictor elevated only MetS. Moreover, found an interaction high-density lipoprotein cholesterol (HDL-C), glycemia, levels, showing a positive correlation HDL-C IGF-1, higher values glycemia MetS.While appear be much impaired diagnosed non-MetS subjects, may respond better parameters lifestyle changes. Further studies are needed role physical activity and/or dietary intervention modulating concentrations survivors.These results could have important clinical implications for planning customized strategies at survivors. In fact, while system seems compromised noMetS