The clinical characteristics, gene mutations and outcomes of myelodysplastic syndromes with diabetes mellitus

• DOI: 10.1007/s00432-023-05591-4
• Publication Date: 2024-02-02T12:02:12Z
• Authors: Fanhuan Xu; Jiacheng Jin; Juan Guo; Feng Xu; Jianan Chen; Qi Liu; Luxi Song; Zheng Zhang; Liyu Zhou; Jiying Su; Chao Xiao; Yumei Zhang; Meng Yan; Qi He; Dong Wu; Chunkang Chang; Xiao Li; Lingyun Wu
• Keywords: Hematology; Clinical Significance

Abstract Purpose Diabetes mellitus (DM) is the second most common comorbidity in myelodysplastic syndromes (MDS). The purpose of study was to investigate clinical characteristics MDS patients with DM. Methods A retrospective analysis performed on data 890 or without Clinical data, including genetic changes, overall survival (OS), leukemia-free (LFS) and infection, were analyzed. Results Among patients, 184 (20.7%) had TET2 SF3B1 mutations occurred more frequently DM group than those non-DM ( p = 0.0092 0.0004, respectively). Besides, an independent risk factor for infection (HR 2.135 CI 1.451–3.110, 0.000) MDS. Compared poor OS LFS 0.0002 0.0017, respectively), especially lower-risk group. While multivariate analysis, did not retain its prognostic significance maintained 2.488 1.749–3.538, 0.000). Conclusions have inferior prognosis which may due higher incidence, being frequent cases.