Pan-cancer analysis to character the clinicopathological and genomic features of KRAS-mutated patients in China

• DOI: 10.1007/s00432-025-06118-9
• Publication Date: 2025-02-28T15:39:28Z
• Authors: Liyuan Wu; Wei Rao; Lei Guo; Fanshuang Zhang; Weihua Li; Jianming Ying
• Keywords: Hematology

The Kirsten rat sarcoma viral oncogene (KRAS) is the most frequently mutated in human cancers. Significant advancements have been made targeted therapy and immunotherapy for this gene recent years, underscoring importance of comprehensively understanding genomic landscape KRAS across various cancer types. Using next-generation sequencing (NGS) technology a panel 520 genes, mutations, tumor mutation burden (TMB), microsatellite instability (MSI-H) status were investigated. An analysis 10,820 samples found mutations 19.97% cases. Pancreatic showed highest prevalence at 73.51%, while colorectal 41.45%, uterine 21.23%, lung 11.24%. G12D common pancreatic, colorectal, gastric cancers, G12V predominant cancer, G12C frequent cancer. correlations between TMB G13D/G12V G13D notably affected uterus was linked to high Moreover, statistical revealed significant association MSI-H cancers digestive, female reproductive, respiratory systems. Specific are associated with MSI