The Analysis of Receptor-binding Cancer Antigen Expressed on SiSo Cells (RCAS1) immunoreactivity within the microenvironment of the ovarian cancer lesion relative to the applied therapeutic strategy

• DOI: 10.1007/s00441-011-1216-4
• Publication Date: 2011-08-17T17:19:39Z
• Authors: Wojciech Jozwicki; Wieslawa Windorbska; Anna A. Brozyna; Cezary Jochymski; Pawel Basta; Jerzy Sikora; Elzbieta Stasienko; Magdalena Dutsch-...; Krzysztof Koper; Lukasz Wicherek
• Keywords: Tumor progression

RCAS1 is involved in generating the suppressive profile of tumor microenvironment that helps cancer cells evade immune surveillance. The status surrounding nest may affect both progression and development metastases. In cases ovarian cancer, a large number patients do not respond to applied therapy. patient's response therapy directly linked intensity its profile. We analyzed immunoreactivity on present with disease; these included macrophages carcinoma-associated fibroblasts. Later we levels within cells, taking into consideration clinical stage therapeutic strategy applied, such as chemotherapy regiments, primary cytoreductive surgery, or presence advanced ascites. who did observed significantly higher than those respond; moreover, non-responsive found staining provide information about immuno-suppressive relate outcome disease.