Risk factors for anastomotic leakage after laparoscopic low anterior resection with DST anastomosis

• DOI: 10.1007/s00464-014-3564-0
• Publication Date: 2014-05-22T20:52:16Z
• Authors: Kenji Kawada; Suguru Hasegawa; Koya Hida; Kenjiro Hirai; Kae Okoshi; Akinari Nomura; Junichiro Kawamura; Satoshi Nagayama; Yoshiharu Sakai
• Keywords: Adult; Aged, 80 and over; Male; Rectal Neoplasms; Anastomosis, Surgical; Operative Time; Rectum; Anastomotic Leak; Middle Aged; Article; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Multivariate Analysis; Surgical Stapling; Odds Ratio; Humans; Lymph Node Excision; Surgery; Female; Laparoscopy; Aged; Retrospective Studies

Laparoscopic rectal surgery involving rectal transection and anastomosis with stapling devices is technically difficult. The aim of this study was to evaluate the risk factors for anastomotic leakage (AL) after laparoscopic low anterior resection (LAR) with double-stapling technique (DST) anastomosis.This was a retrospective single-institution study of 154 rectal cancer patients who underwent laparoscopic LAR with DST anastomosis between June 2005 and August 2013. Patient-, tumor-, and surgery-related variables were examined by univariate and multivariate analyses. The outcome of interest was clinical AL.The overall AL rate was 12.3% (19/154). In univariate analysis, tumor size (P = 0.001), operative time (P = 0.049), intraoperative bleeding (P = 0.037), lateral lymph node dissection (P = 0.009), multiple firings of the linear stapler (P = 0.041), and precompression before stapler firings (P = 0.008) were significantly associated with AL. Multivariate analysis identified tumor size (odds ratio [OR] 4.01; 95% confidence interval [CI] 1.25-12.89; P = 0.02) and precompression before stapler firings (OR 4.58; CI 1.22-17.20; P = 0.024) as independent risk factors for AL. In particular, precompression before stapler firing tended to reduce the AL occurring in early postoperative period.Using appropriate techniques, laparoscopic LAR with DST anastomosis can be performed safely without increasing the risk of AL. Important risk factors for AL were tumor size and precompression before stapler firings.