Haemodialysing babies weighing <8 kg with the Newcastle infant dialysis and ultrafiltration system (Nidus): comparison with peritoneal and conventional haemodialysis

• DOI: 10.1007/s00467-014-2923-3
• Publication Date: 2014-08-14T20:36:35Z
• Authors: Malcolm G. Coulthard; Jean Crosier; Clive Griffiths; Jon Smith; Michael Drinnan; Mike Whitaker; Robert Beckwith; John N. S. Matthews; Paul Flecknell; Heather J. Lambert
• Keywords: Ultrafiltration (renal)

To compare the efficacy of Newcastle infant dialysis and ultrafiltration system (Nidus) with peritoneal (PD) conventional haemodialysis (HD) in infants weighing <8 kg.We compared urea, creatinine phosphate clearances, precision, safety Nidus machine PD 7 piglets 1-8 kg, a planned randomised cross-over trial babies, babies for whom no other therapy existed, some later graduated to HD.Two entered trial; 1 recovered rapidly on PD, remained as failed. Additionally, 9 were treated humanitarian grounds: 3 because failed permanent kidney failure converted HD. We haemodialysed 10 between 1.8 5.9 kg 2,475 h during 354 sessions without any clinically important incidents, detectable haemolysis. Single-lumen vascular access was used blood priming circuits. The clearances using around 1.5 2.0 ml/min consistently higher than which ranged from about 0.2 0.8 (p ≤ 0.0002 each chemical). Ultrafiltration achieved microlitre precision by Nidus, but varied widely PD. Fluid removal HD imprecise resulted hypovolaemic episodes requiring correction.The can provide Pediatric Intensive Care Unit (PICU) outpatient intermittent It generates delivers more precise control either or