Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis?

• DOI: 10.1007/s00467-014-2999-9
• Publication Date: 2014-11-12T16:28:41Z
• Authors: Elżbieta Kuroczyc...; Tadeusz Porowski; Piotr T. Protas; Marta Pszczółkowska; Halina Porowska; Jan K. Kirejczyk; Anna Wasilewska
• Keywords: Male; 2. Zero hunger; Adolescent; Hyperuricemia; Uric Acid; 3. Good health; Electrolytes; 03 medical and health sciences; 0302 clinical medicine; Urolithiasis; Nephrology; Risk Factors; Humans; Original Article; Female; Pediatrics, Perinatology, and Child Health; Obesity; Child

There are indications that obesity and hyperuricemia may influence the formation composition of urinary stones. The aim our study was to determine effect on lithogenic risk profile in a large cohort pediatric patients. population comprised 478 children with urolithiasis 517 healthy (reference group). We studied effects by dividing patients into two groups based body mass index Z-score (patients who were overweight/obese vs. those normal weight for age) comparing groups. To profile, we divided presence or not (110 accompanied 368 serum uric acid levels) compared Among adolescents hyperuricemia, there significantly lower excretion crystallization inhibitors (citrates, magnesium). also found negative correlations between levels urine citrate/creatinine ratio (citrate/cr.; r = −0.30, p < 0.01), as well magnesium/cr. (Mg/cr.; −0.33, 0.01). no statistically significant differences oxalates, citrates, calcium, phosphorus, magnesium either overweight obese had weight. In patient cohort, associated decrease urine, but clinical relevance this observation needs be confirmed future studies. Obesity direct stone formers study, an indication higher impairment renal function, which turn could parameters.