Dyslipidemia in children with chronic kidney disease—findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study

• DOI: 10.1007/s00467-024-06389-3
• Publication Date: 2024-05-08T22:01:31Z
• Authors: Francesca Mencarelli; Karolis Azukaitis; Marietta Kirchner; Aysun Bayazit; Ali Duzova; Nur Canpolat; Ipek Kaplan Bulut; Lukasz Obrycki; Bruno Ranchin; Rukshana Shroff; Salim Caliskan; Cengiz Candan; Alev Yilmaz; Zeynep Birsin Özc...; Harika Halpay; Aysel Kiyak; Hakan Erdogan; Jutta Gellermann; Ayse Balat; Anette Melk; Franz Schaefer; Uwe Querfeld
• Keywords: Dyslipidemia; Nephrology

Abstract Background Dyslipidemia is an important and modifiable risk factor for CVD in children with CKD. Methods In a cross-sectional study of baseline serum lipid levels large prospective cohort stage 3–5 (predialysis) CKD, frequencies abnormal types dyslipidemia were analyzed the entire subpopulations defined by fasting status or presence nephrotic range proteinuria. Associated clinical laboratory characteristics determined multivariable linear regression analysis. Results A total 681 patients aged 12.2 ± 3.3 years mean eGFR 26.9 11.6 ml/min/1.73 m 2 included. Kidney diagnosis was classified as CAKUT 69%, glomerulopathy 8.4%, other disorders 22.6% patients. Nephrotic proteinuria (defined urinary albumin/creatinine ratio > 1.1 g/g) present 26.9%. found 71.8%, high triglyceride (TG) most common abnormality (54.7%). Fasting (38.9%) had no effect on status. Except significant increase TG more advanced not significantly different between CKD stages. Hypertriglyceridemia associated younger age, lower eGFR, shorter duration higher body mass index (BMI-SDS), albumin, diastolic blood pressure. Conclusions involving all fractions, but mainly TG, majority irrespective cardiovascular factors. Graphical abstract