Knock-on effect of periodontitis to the pathogenesis of Alzheimer’s disease?

• DOI: 10.1007/s00508-020-01638-5
• Publication Date: 2020-03-25T10:02:35Z
• Authors: Friedrich Leblhuber; Julia Huemer; Kostja Steiner; Johanna M. Gostner; Dietmar Fuchs
• Keywords: Treponema denticola; Tannerella forsythia; Oral Microbiome; Pathogenesis

Summary Background Alzheimer’s disease has chronic inflammatory components, which can be enhanced by systemic immune activation resulting in inflammation or vice versa . There is growing evidence that periodontitis drives and finally disease. Thus, a link might exist between oral pathogens This may of special significance as there an age-related incidence periodontitis. Methods In this study, 20 consecutive patients with probable were investigated. Diagnosis was established cognitive tests, routine laboratory tests cerebral magnetic resonance tomography. 35% these impairment pathogenic periodontal bacteria found. Results The presence Porphyromonas gingivalis , the key pathogen one species involved periodontitis, found to associated lower mini mental state examination scores ( p < 0.05) tendency clock drawing test = 0.056). Furthermore, association serum concentrations biomarker neopterin Treponema denticola 0.01) well kynurenine Alzheimer positive vs. negative for Tannerella forsytia 0.05). Conclusions Data indicate possible specific impairment, alter host response Albeit still preliminary, findings study point role altered salivary microbiome causal