Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma

• DOI: 10.1007/s00534-012-0581-z
• Publication Date: 2012-12-26T05:37:03Z
• Authors: Hiroki Kawashima; Akihiro Itoh; Eizaburo Ohno; Ryoji Miyahara; Naoki Ohmiya; Tsutomu Tanaka; Yoshie Shimoyama; Shigeo Nakamura; Tomoki Ebata; Masato Nagino; Hidemi Goto; Yoshiki Hirooka
• Keywords: Bile duct cancer; Univariate analysis; Histology

Because the biopsy specimen of extrahepatic bile duct carcinoma (EHBDC) is small and shows reactive changes, histological distinction between malignant benign tissue can be difficult. Recent studies reported that S100P insulin-like growth factor II mRNA-binding protein 3 (IMP3) were not only diagnostic molecules but also prognostic biomarkers in several organs. The objective this study to clarify value immunohistochemical expression IMP3 transpapillary biliary forceps (TBFB) samples.The TBFB samples collected from 80 patients (EHBDC, 68 patients; benign, 12 patients), retrospectively.When using cytoplasmic-positive staining for as a marker malignancy, sensitivity specificity reached 79.4 91.7 %, respectively. sensitivity, accuracy achieved 89.7, 90.0 respectively, when positive and/or histology maker malignancy. While univariate (P = 0.033) multivariate 0.039) analysis revealed S100P-positive EHBDC showed significantly shorter survival.The results suggest useful diagnosis EHBDC.