Clinical usefulness of urinary liver-type fatty-acid-binding protein as a perioperative marker of acute kidney injury in patients undergoing endovascular or open-abdominal aortic aneurysm repair

• DOI: 10.1007/s00540-015-2095-8
• Publication Date: 2015-11-19T09:16:01Z
• Authors: Yumi Obata; Atsuko Kamijo-Ike...; Daisuke Ichikawa; Takeshi Sugaya; Kenjiro Kimura; Yugo Shibagaki; Takeshi Tateda
• Keywords: Aged, 80 and over; Male; Endovascular Procedures; Acute Kidney Injury; Fatty Acid-Binding Proteins; 3. Good health; 03 medical and health sciences; Anesthesiology and Pain Medicine; 0302 clinical medicine; ROC Curve; Humans; Original Article; Female; Postoperative Period; Prospective Studies; Biomarkers; Aged; Aortic Aneurysm, Abdominal

Acute kidney injury (AKI) is common after cardiovascular surgery and usually diagnosed on the basis of serum creatinine (SCr) level urinary output. However, SCr low sensitivity in patients with poor renal function. Because liver-type fatty-acid-binding protein (L-FABP) reflects tubular injury, we evaluated whether perioperative changes L-FABP predict AKI context abdominal aortic repair. Study participants were 95 who underwent endovascular aneurysm repair (EVAR) 42 open We obtained urine samples before surgery, anesthesia induction, upon stent placement, cross-clamping (AXC), 1 2 h AXC, at end 4 postoperative days (PODs) 1, 2, 3, for measurement L-FABP. immediately PODs SCr. also plotted receiver-operating characteristic (ROC) curves to identify cutoff laboratory values predicting onset AKI. With EVAR, was significantly increased procedure (P = 0.014). repair, its maximum by AXC 0.007). AKI, < 0.001, P 0.001) POD 2. ROC analysis showed be more sensitive than early detection Urinary appears a biomarker undergoing