Integrated transcriptomics and metabolomics analysis reveals the biomolecular mechanisms associated to the antitumoral potential of a novel silver-based core@shell nanosystem

• DOI: 10.1007/s00604-023-05712-3
• Publication Date: 2023-03-13T19:02:40Z
• Authors: Guillermo Aragone...; María Vallet-Regí; Ma. Milagros Góme...; Blanca González; Jose L. Luque-Garcia
• Keywords: Original Paper; Silver; Transferrin; Metabolomics; Nanoparticles; Antineoplastic Agents; Transcriptome

A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for antitumor action a nanosystem based on Ag core coated with mesoporous silica which transferrin anchored as targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis carried out by gene microarrays RT-qPCR, while high-resolution mass spectrometry metabolomics. This multi-omics strategy enabled discovery effect this different key molecular pathways including glycolysis, pentose phosphate pathway, oxidative phosphorylation synthesis fatty acids, among others.