Clip ligation of unruptured intracranial aneurysms: a prospective midterm outcome study

• DOI: 10.1007/s00701-012-1397-y
• Publication Date: 2012-05-28T15:15:27Z
• Authors: Yunus Aydın; Halit Çavuşoğlu; Okan Kahyaoğlu; Ahmet Murat Müslüman; Adem Yılmaz; Osman Nuri Türkme...; Songül Meltem Can; İsmail Yüce
• Keywords: Adult; Male; Patient Selection; Angiography, Digital Subtraction; Intracranial Aneurysm; Middle Aged; Surgical Instruments; Cerebral Angiography; 3. Good health; Disability Evaluation; 03 medical and health sciences; Postoperative Complications; Treatment Outcome; 0302 clinical medicine; Humans; Female; Prospective Studies; Tomography, X-Ray Computed; Ligation; Craniotomy; Magnetic Resonance Angiography; Aged; Follow-Up Studies

We conducted a prospective study to investigate the clinical and radiological outcome in a surgical case series of 176 patients with 203 unruptured intracranial aneurysms (UIA).The success of aneurysm obliteration was assessed within 2 weeks after surgery by digital subtraction angiography (DSA). Patients also underwent angiography 5 years after surgery. Clinical outcomes were assessed using the modified Rankin Scale (mRS). All predictors of poor surgical outcomes were assessed using an exact logistic regression.Overall, 83 % of the patients had a good outcome (mRS score 0 or 1); 10.8 % of the patients had a slight disability (mRS score 2), and 6.2 % of the patients had a moderate or moderate-severe disability (mRS score 3 or 4). The mortality rate was 0 % overall. The most important predictors of outcome were presence of history of ischemic cerebrovascular disease and postoperative stroke. Complete aneurysm occlusion was achieved in 93.5 % of all aneurysms. Sixty percent of treated aneurysms were checked with late follow-up DSA. No cases of hemorrhage from a surgically obliterated UIA were documented in this series during the 7.3 ± 1.4 (SD)-year follow-up period.If patients are carefully selected and individually assigned to their optimum treatment modality, IUAs can be obliterated by surgery with a low percentage of unfavorable outcomes.