Proteins involved in regulating bone invasion in skull base meningiomas

• DOI: 10.1007/s00701-012-1577-9
• Publication Date: 2012-12-12T04:40:29Z
• Authors: Fateme Salehi; Shahrzad Jalali; Ryan Alkins; Joon-Il Lee; Shelly Lwu; Kelly Burrell; Fred Gentili; Sidney Croul; Gelareh Zadeh
• Keywords: Osteopontin; MMP2; MMP1

Bone invasive skull base meningiomas are a subset of that present unique clinical challenge due to brain and neural structure involvement limitations in complete surgical resection, resulting higher recurrence need for repeat surgery. To date, the pathogenesis meningioma bone invasion has not been investigated. We investigated immunoexpression proteins implicated other tumor types establish their invasion.Retrospective review our database identified operated on at institution over past 20 years. Using high-throughput tissue microarray (TMA), we established expression profile osteopontin (OPN), matrix metalloproteinase-2 (MMP2), integrin beta-1 (ITGB1). Differential cell vasculature was evaluated comparisons were made between anatomical locations.MMP2, OPN, ITGB1 immunoreactivity cytoplasmic and/or endothelial cells. Noninvasive transbasal exhibited vascular MMP2 compared meningiomas. found levels OPN noninvasive Strong extending from endothelium through media into adventitia meningiomas.We have demonstrated key differentially expressed location is determinant pattern MMP1, ITGB1. This data provides initial insights pathophysiology identifies factors can be pursued as potential therapeutic targets.