Improved outcomes associated with maximal extent of resection for butterfly glioblastoma: insights from institutional and national data

• DOI: 10.1007/s00701-021-04844-w
• Publication Date: 2021-04-19T04:02:54Z
• Authors: Alessandro Boaro; Vasileios K. Kavo...; Francesca Siddi; Elisabetta Mezzalira; Maya Harary; J. Bryan Iorgulescu; David A. Reardon; Timothy R. Smith
• Keywords: Brain Neoplasms; Corpus callosum; Biopsy; DNA Methylation; Prognosis; 3. Good health; 03 medical and health sciences; Butterfly glioblastoma; DNA Repair Enzymes; 0302 clinical medicine; Extent of resection; Humans; Female; Glioblastoma; Promoter Regions, Genetic; DNA Modification Methylases

Butterfly glioblastomas (bGBMs) are grade IV gliomas that infiltrate the corpus callosum and spread to bilateral cerebral hemispheres. Due to the rarity of cases, there is a dearth of information in existing literature. Herein, we evaluate clinical and genetic characteristics, associated predictors, and survival outcomes in an institutional series and compare them to a national cohort.We identified all adult patients with bGBM treated at Brigham & Women's Hospital (2008-2018). The National Cancer Database (NCDB) was also queried for bGBM patients. Survival was analyzed with Kaplan-Meier methods, and Cox models were built to assess for predictive factors.Of 993 glioblastoma patients, 62 cases (6.2%) of bGBM were identified. Craniotomy for resection was attempted in 26 patients (41.9%), with a median volumetric extent of resection (vEOR) of 72.3% (95% confidence interval [95%CI] 58.3-82.1). The IDH1 R132H mutation was detected in two patients (3.2%), and MGMT promoter was methylated in 55.5% of the assessed cases. In multivariable regression, factors predictive of longer OS were increased vEOR, MGMT promoter methylation, and receipt of adjuvant therapy. Median OS for the resected cases was 11.5 months (95%CI 7.7-18.8) vs. 6.3 (95%CI 5.1-8.9) for the biopsied. Of 21,353 GBMs, 719 (3.37%) bGBM patients were identified in the NCDB. Resection was more likely to be pursued in recent years, and GTR was independently associated with prolonged OS (p < 0.01).Surgical resection followed by adjuvant chemoradiation is associated with significant survival gains and should be pursued in carefully selected bGBM patients.