Queckenstedt’s test repurposed for the quantitative assessment of the cerebrospinal fluid pulsatility curve

• DOI: 10.1007/s00701-023-05583-w
• Publication Date: 2023-04-20T15:21:41Z
• Authors: Najmeh Kheram; Andrea Boraschi; Nikolai Pfender; Andreas Spiegelberg; Vartan Kurtcuoglu; Armin Curt; Martin Schubert; Carl Moritz Zipser
• Keywords: Cerebrospinal fluid pressure; Pulsatile flow

Abstract Purpose Before the era of spinal imaging, presence a canal block was tested through gross changes in cerebrospinal fluid pressure (CSFP) provoked by manual compression jugular veins (referred to as Queckenstedt's test; QT). Beyond these changes, cardiac-driven CSFP peak-to-valley amplitudes (CSFPp) can be recorded during registration. This is first study assess whether QT repurposed derive descriptors CSF pulsatility curve, focusing on feasibility and repeatability. Method Lumbar puncture performed lateral recumbent position fourteen elderly patients (59.7±9.3 years, 6F) (NCT02170155) without stenosis canal. resting state QT. A surrogate for relative pulse coefficient computed from repeated QTs (i.e., RPPC-Q). Results Resting mean 12.3 mmHg (IQR 3.2) CSFPp 1.0 (0.5). Mean rise 12.5 (7.3). showed an average 3-fold increase at peak compared state. Median RPPC-Q 0.18 (0.04). There no systematic error metrics between second Conclusion technical note describes method reliably derive, beyond increments, related comparing obtained established procedures infusion testing) warranted.