A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water

• DOI: 10.1007/s00706-012-0822-5
• Publication Date: 2012-08-15T07:21:45Z
• Authors: Qinghua Lv; Lizhen Fang; Pengfei Wang; Chenjuan Lu; Fulin Yan
• Keywords: Isatin; Quinoline; Condensation reaction; Reaction conditions; Generality

AbstractAn optimized procedure is given for the reaction of isatin with ketones to afford title quinoline compounds (III) which are otherwise difficult to prepare.