Synthesis of 1,5-disubstituted tetrazoles containing a fragment of the anticancer drug imatinib via a microwave-assisted Ugi-azide reaction

• DOI: 10.1007/s00706-016-1686-x
• Publication Date: 2016-02-23T07:34:51Z
• Authors: Carlos J. Cortes-...; Alejandro Islas-J...; Angel Rentería-Gómez; Rocío Gámez-Montaño
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

AbstractThe title tetrazoles (30 examples) may exhibit cytotoxicity and/or tyrosine‐kinase inhibitory properties because of their structural similarities with potent cancer drugs such as imatinib.