Applying polygenic risk scores to postpartum depression

• DOI: 10.1007/s00737-014-0428-5
• Publication Date: 2014-07-18T01:49:42Z
• Authors: Enda M. Byrne; Tania Carrillo-Roa; Brenda W. J. H. P...; Hannah M. Sallis; Alexander Viktorin; Brett Chapman; Anjali K. Henders; Michele L. Pergadia; Andrew C. Heath; Pamela A. F. Madden; Patrick F. Sullivan; Lynn Boschloo; Gerard van Grooth...; George McMahon; Debbie A. Lawlor; Mikael Landén; Paul Lichtenstein; Patrik K. E. Magn...; David M. Evans; Grant W. Montgomery; Dorret I. Boomsma; Nicholas G. Martin; Samantha Meltzer-...; Naomi R. Wray
• Keywords: Netherlands Twin Register (NTR); Adult; Male; Multifactorial Inheritance; Bipolar Disorder; 330; Genotype; 610; Polymorphism, Single Nucleotide; 2729 Obstetrics and Gynaecology; Depression, Postpartum; Young Adult; 03 medical and health sciences; 0302 clinical medicine; SDG 3 - Good Health and Well-being; Postpartum; Risk Factors; Surveys and Questionnaires; 2738 Psychiatry and Mental health; 616; Humans; Genetic Predisposition to Disease; Polymorphism; Retrospective Studies; Depressive Disorder; Depressive Disorder, Major; Depression; Bipolar Disorder/genetics; Genetic Variation; Major/genetics; Single Nucleotide; 3. Good health; Logistic Models; Bipolar; Female; Postpartum/genetics

The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis.