Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

• DOI: 10.1007/s00784-023-04909-3
• Publication Date: 2023-02-14T11:52:15Z
• Authors: Daniela Adamo; Elena Calabria; Federica Canfora; Noemi Coppola; Stefania Leuci; Martina Mignogna; Lorenzo Lo Muzio; Francesca Spirito; Michele Giuliani; Lorenzo Azzi; Marta Dani; Giuseppe Colella; Chiara Colella; Lucio Montebugnoli; Davide Bartolomeo...; Mario Gabriele; Marco Nisi; Andrea Sardella; Giovanni Lodi; Elena Maria Varoni; Amerigo Giudice; Alessandro Antonelli; Alessio Gambino; Giuliana Antonucci; Paolo Vescovi; Marco Meleti; Alessandra Majorana; Elena Bardellini; Giuseppina Campisi; Vera Panzarella; Francesco Spadari; Umberto Garagiola; Monica Pentenero; Samuele Sutera; Matteo Biasotto; Giulia Ottaviani; Margherita Gobbo; Luca Guarda Nardini; Umberto Romeo; Gianluca Tenore; Rosario Serpico; Alberta Lucchese; Carlo Lajolo; Gioele Gioco; Massimo Aria; Luca D’Aniello; Michele Davide Mi...
• Keywords: Depression; Oral Lichen Planus

Abstract Objectives Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated complex symptomatology and psychological alteration. The aim the study was to evaluate prevalence anxiety (A) depression (D) in patients K-OLP, analyzing potential predictors which can affect mental health status. Methods Three hundred K-OLP versus 300 healthy controls (HC) were recruited 15 Italian universities. Numeric Rating Scale (NRS), Total Pain Index (T-PRI), Hamilton Scales for Depression Anxiety (HAM-D HAM-A) administered. Results showed statistically higher scores NRS, T-PRI, HAM-D, HAM-A compared HC ( p -value < 0.001 ** ). A D found 158 (52.7%) 148 (49.3%) patients. Strong linear correlations identified between HAM-A, employment status status, female gender. Multivariate logistic regression revealed HAM-D greatest increase R2 value patients, respectively (DR2 = 55.5% 0.001**; DR2 56.5% 0.001**). Conclusions HC, also subjects without pain, suggesting processing pain certain way independent mood. Clinical relevance Mood disorders assessment should carefully performed relation obtain complete analysis