Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial

• DOI: 10.1007/s00784-024-05610-9
• Publication Date: 2024-03-26T16:02:19Z
• Authors: Rui Li; Wenjie Yang; Roberta Grimaldi; Peter Zeng; Gary Smith; Xi Chen
• Keywords: Dentifrice; Dentin hypersensitivity; Sodium fluoride

Abstract Objectives To compare the effectiveness of using a 0.454% stannous fluoride-containing dentifrice twice daily in relieving dentinal hypersensitivity (DH) Chinese population. Materials and methods This was single-centre, randomized, controlled, examiner-blind, three-treatment-arm, parallel-group study participants with clinically diagnosed DH. Subjects who met inclusion criteria (n = 197) were randomly allocated into 3 groups: test group 66)—using daily; positive control 64)—using 5.0% calcium sodium phosphosilicate-containing negative 67)—using 1150 ppm NaF daily. Status DH assessed at week 4 8 by same independent examiner. Changes from baseline Schiff sensitivity score, tactile threshold Dentine Hypersensitivity Experience Questionnaire (DHEQ) score analysed analysis covariance models. The DHEQ evaluated subject-perceived oral health-related quality life (OHRQoL). Results Statistically significant improvements mean scores (p < 0.0001 for all products Weeks 8), 8: Week p 0.0040 control) 0.01 groups) observed. No statistically differences observed adjusted between dentifrices both timepoints, potentially driven placebo effect. Forty-two treatment-emergent adverse events (TEAEs) reported 32 subjects), 2 serious AEs 1) group. TEAEs not considered treatment-related. Conclusions All groups demonstrated OHRQoL. However, due to possible effect control, there no dentifrices. Clinical relevance adds growing research exploring why is common phenomenon studies. Trial registration: ClinicalTrials.gov Identifier: NCT04950465.