Molecular mechanism of vSGLT inhibition by gneyulin reveals antiseptic properties against multidrug-resistant gram-negative bacteria

• DOI: 10.1007/s00894-019-4073-9
• Publication Date: 2019-06-11T06:02:35Z
• Authors: Daniel Wiczew; Anna Borowska; Kinga Szkaradek; Tomasz Biegus; Kamil Wozniak; Marcelina Pyclik; Magdalena Sitarska; Lukasz Jaszewski; Lukasz Radosinski; Beata Hanus-Lorenz; Sebastian Kraszewski
• Keywords: Antiseptic; Gram-Negative Bacteria; Gram

Faced with the worldwide spread of multidrug-resistant (MDR) bacterial strains, together a lack any appropriate treatment, urgent steps to combat infectious diseases should be taken. Usually, components are studied understand, by analogy, functioning human proteins. However, molecular data from bacteria gathered over past decades provide sound basis for search novel approaches in medical care. With this current work, we want direct attention inhibition vSGLT glucose transporter Vibrio parahaemolyticus belonging sodium solute symporter (SSS) family, block sugar transport into cell and, as consequence, limit its growth. Potential bacteriostatic properties can drawn commercially available drugs developed diseases. This goal also reached natural traditional herbal medicine. The presented numerical analysis 44 known inhibitors symporters shed light on potential fighting Gram-negative microorganisms.