Alteration of LV end-diastolic volume by controlling the power of the continuous-flow LVAD, so it is synchronized with cardiac beat: development of a native heart load control system (NHLCS)

• DOI: 10.1007/s10047-011-0615-3
• Publication Date: 2011-11-11T12:20:04Z
• Authors: Akihide Umeki; Takashi Nishimura; Masahiko Ando; Yoshiaki Takewa; Kenji Yamazaki; Shunei Kyo; Minoru Ono; Tomonori Tsukiya; Toshihide Mizuno; Yoshiyuki Taenaka; Eisuke Tatsumi
• Keywords: Ventricular Dysfunction, Left; 03 medical and health sciences; 0302 clinical medicine; Heart Rate; Goats; Models, Cardiovascular; Animals; Heart-Assist Devices; Pulse; 3. Good health

There are many reports comparing pulsatile and continuous-flow left ventricular assist devices (LVAD). But continuous-flow LVAD with the pulsatile driving technique had not been tried or discussed before our group's report. We have previously developed and introduced a power-control unit for a centrifugal LVAD (EVAHEART®; Sun Medical), which can change the speed of rotation so it is synchronized with the heart beat. By use of this unit we analyzed the end-diastolic volume (EDV) to determine whether it is possible to change the native heart load. We studied 5 goats with normal hearts and 5 goats with acute LV dysfunction because of micro-embolization of the coronary artery. We used 4 modes, "circuit-clamp", "continuous", "counter-pulse", and "co-pulse", with the bypass rate (BR) 100%. We raised the speed of rotation of the LVAD in the diastolic phase with the counter-pulse mode, and raised it in the systolic phase with the co-pulse mode. As a result, the EDV decreased in the counter-pulse mode and increased in the co-pulse mode, compared with the continuous mode (p < 0.05), in both the normal and acute-heart-failure models. This result means it may be possible to achieve favorable EDV and native heart load by controlling the rotation of continuous-flow LVAD, so it is synchronized with the cardiac beat. This novel driving system may be of great benefit to patients with end-stage heart failure, especially those with ischemic etiology.