Vocabulary knowledge as a reliable proxy of cognitive reserve in multiple sclerosis: a validation study

• DOI: 10.1007/s10072-024-07388-w
• Publication Date: 2024-02-28T17:02:29Z
• Authors: Gianpaolo Maggi; Manuela Altieri; Mario Risi; Valentina Rippa; Riccardo Maria Borgo; Rosaria Sacco; Daniela Buonanno; Alessandro D’Ambr...; Alvino Bisecco; Gabriella Santangelo; Antonio Gallo
• Keywords: Montreal Cognitive Assessment; Cognitive reserve

Abstract Introduction The present study aimed to explore the suitability of vocabulary knowledge (VOC) test as an accurate and reliable proxy cognitive reserve (CR) by evaluating its psychometric properties discrimination accuracy compared with other CR measures in multiple sclerosis (MS). Methods Sixty-eight consecutive people (pwMS), followed at our MS outpatient clinic, completed a clinical evaluation neuropsychological assessment including: VOC, Brief Repeatable Battery Neuropsychological Tests (BRB-N), Cognitive Reserve Index Questionnaire (CRIq), Beck Depression Inventory-II, State-Trait Anxiety Inventory. Reliability, convergent divergent validity, VOC were assessed using educational level reference standard. possible effects sociodemographic factors on their role predicting global status also explored. Results demonstrated good internal consistency (Cronbach’s α = 0.894) adequate construct validity. It showed acceptable between pwMS high low CR, comparable CRIq score. Education strongly affected scores, which turn independent features. emerged predictor together MS-related disability. Conclusion We validity measure pwMS. Thus, may be estimated fixed objective measures, brain pathology Early estimation help clinicians identify higher risk decline plan strict monitoring interventions.