Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients

• DOI: 10.1007/s10096-011-1182-5
• Publication Date: 2011-01-30T01:47:00Z
• Authors: A. Lambiase; M. R. Catania; M. del Pezzo; F. Rossano; V. Terlizzi; A. Sepe; V. Raia
• Keywords: Achromobacter xylosoxidans; Medical microbiology; Sputum culture; DNA profiling

The aims of this study were to evaluate the frequency Achromobacter xylosoxidans infection in a cohort cystic fibrosis patients, investigate antimicrobial sensitivity, establish possible clonal likeness among strains, and address clinical impact or colonization on general outcome these patients. was undertaken between January 2004 December 2008 300 patients receiving care at Regional Cystic Fibrosis Center Naples University "Federico II". Sputum samples checked for bacterial identification. For DNA fingerprinting, pulsed-field gel electrophoresis (PFGE) carried out. Fifty-three (17.6%) had least one positive culture A. xylosoxidans; these, 6/53 (11.3%) defined as chronically infected all co-colonized by Pseudomonas aeruginosa. Of 18.8% persistently multidrug-resistant isolates. Macrorestriction analysis showed presence seven major clusters. fingerprinting also genetic relationship strains isolated from same different times. results indicate evidence enrolled We found no significant differences forced expiratory volume 1 s (FEV(1)) body mass index (BMI) when comparing case group with control P. aeruginosa