Clinical and microbiological features associated with group B Streptococcus bone and joint infections, France 2004–2014

• DOI: 10.1007/s10096-017-2983-y
• Publication Date: 2017-04-26T08:15:45Z
• Authors: S. Kernéis; C. Plainvert; J.-P. Barnier; A. Tazi; N. Dmytruk; B. Gislain; J. Loubinoux; F. El Sayed; V. Cattoir; N. Desplaces; V. Vernet; P. Morand; C. Poyart
• Keywords: Adult; Aged, 80 and over; Male; Arthritis, Infectious; 0303 health sciences; Adolescent; Osteomyelitis; Comorbidity; Microbial Sensitivity Tests; Middle Aged; History, 21st Century; Streptococcus agalactiae; 3. Good health; Young Adult; 03 medical and health sciences; Streptococcal Infections; Drug Resistance, Bacterial; Humans; Female; France; Aged; Multilocus Sequence Typing

This study describes the clinical and microbiological features associated with group B Streptococcus (GBS) bone and joint infections (BJIs). It was a retrospective analysis of adult cases of GBS BJIs reported to the French National Reference Center for Streptococci from January 2004 to December 2014. Clinical data and GBS molecular characteristics are reported. Strains were collected from 163 patients. The most frequent comorbidities were: solid organ cancer (n = 21, 21%) and diabetes mellitus (n = 20, 20%). The main infection sites were knee (47/155 = 30%) and hip (43/155 = 27%), and occurred on orthopedic devices in 71/148 cases (48%). CPS III (n = 47, 29%), Ia (n = 26, 16%) and V (n = 40, 25%) were predominant. Resistance to erythromycin, clindamycin and tetracycline was detected in 55/163 (34%), 35/163 (21%) and 132/163 (81%) strains, respectively. The most frequent sequence types were ST-1 (n = 21, 25%), ST-17 (n = 17, 20%) and ST-23 (n = 11, 13%). The rate of resistance to erythromycin was 0% for ST-17 strains, 52% (n = 11) for ST-1 and 44% (n = 7) for ST-23 (p < 0.001). GBS bone and joint infections predominantly occur in patients aged >50 years and/or with comorbidities such as cancer and diabetes mellitus. CPS type distribution and MLST are very similar to that of other adult GBS invasive infections.