Use of other antimicrobial drugs is associated with trimethoprim resistance in patients with urinary tract infections caused by E. coli

• DOI: 10.1007/s10096-019-03672-2
• Publication Date: 2019-09-07T11:02:51Z
• Authors: M. Mulder; A. Verbon; J. Lous; W. Goessens; B. H. Stricker
• Keywords: Nitrofurantoin; Trimethoprim

In recent years, high frequencies of trimethoprim resistance in urinary tract infections (UTIs) caused by E. coli are have been reported. Co-resistance to other antimicrobial drugs may play a role this increase. Therefore, we investigated whether previous use was associated with resistance. We conducted nested case-control study cultures from participants the Rotterdam Study sent general practitioners regional laboratory between 1 January 2000 and April 2016. Multivariable logistic regression analysis performed association prior prescriptions several drug groups using individual participant data. Urinary 1264 individuals UTI were included. When adjusted for use, history > 3 extended-spectrum penicillins (OR 1.68; 95% CI 1.10-2.55) significantly as sulfonamides 2.22; 1.51-3.26). The nitrofuran derivatives lower frequency 0.60; 0.39-0.92), after adjustment prescriptions. found that is On contrary, nitrofurantoin Especially recurrent UTI, co-resistance should be taken into account susceptibility testing before starting considered.