Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia

• DOI: 10.1007/s10096-020-03831-w
• Publication Date: 2020-07-08T10:03:43Z
• Authors: Elena Shipitsyna; Tatiana Khusnutdi...; Olga Budilovskaya; Anna Krysanova; Kira Shalepo; Alevtina Savicheva; Magnus Unemo
• Keywords: Mycoplasma genitalium; Lactobacillus crispatus; Vaginal flora; Gardnerella vaginalis

Abstract The large majority of studies investigating associations between bacterial vaginosis (BV) and sexually transmitted infections (STIs) have been conducted among predominantly young women with high risk for STIs. Since a risky sexual behavior is significant factor both STIs BV, this creates bias toward an increased association BV This study evaluated BV-associated vaginal microbiota ( Chlamydia trachomatis , Mycoplasma genitalium Trichomonas vaginalis Neisseria gonorrhoeae ) in population low investigated STI outcomes depending on the dominating Lactobacillus species. Repository cervicovaginal samples collected from reproductive-age January 2014 to February 2019 were characterized types using multiplex real-time PCR assays. In total, 95 STI-positive 91 STI-negative included. A significant, age-independent presence C. M. T. was identified (age-adjusted odds ratios 2.92 [95% confidence interval (CI) 1.24–7.03], 2.88 CI 1.19–7.16], 9.75 × 10 7 13.03-∞], respectively). Normal dominated by crispatus, L. gasseri, or jensenii strong protective against and/or infections, whereas iners -dominated not significantly associated positivity. results present confirm that prevention strategies should include interventions also reduce incidence promote high- low-risk women.