Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

• DOI: 10.1007/s10096-020-03925-5
• Publication Date: 2020-07-08T10:03:43Z
• Authors: Marie Decalonne; Sandra Dos Santos; Rémi Gimenes; Florent Goube; Géraldine Abadie; Saïd Aberrane; Vanina Ambrogi; Raoul Baron; Patrick Barthelemy; Isabelle Bauvin; Olivier Belmonte; Emilie Benabid; Rafik Ben Ammar; Salma Ben Hadj Yahia; Yasmina Berrouane; Philippe Berthelot; Alain Beuchee; Emmanuelle Bille; Pascal Bolot; Stéphanie Bordes-...; Antoine Bouissou; Sandra Bourdon; Nadège Bourgeois-...; Sophie Boyer; Christian Cattoen; Vincent Cattoir; Chantal Chaplain; Céline Chatelet; Aurore Claudinon; Nathalie Chautemps; Hélène Cormier; Céline Coroller-Bec; Benjamin Cotte; Carole De Chillaz; Olivier Dauwalder; Aude Davy; Martine Delorme; Maryvonne Demasure; Luc Desfrere; Michel Drancourt; Clarisse Dupin; Véronique Faraut-...; Arnaud Florentin; Virginie Forget; Nicolas Fortineau; Tania Foucan; Pierre Frange; Karine Gambarotto; Géraldine Gascoin; Laure Gibert; Jacques Gilquin; Audrey Glanard; Jacqueline Grando; Alain Gravet; Jérôme Guinard; Geneviève Hery-Ar...; Claire Huart; Nadia Idri; Jean-Marc Jellimann; Olivier Join-Lambert; Sylvie Joron; Philippe Jouvencel; Marie Kempf; Sophie Ketterer-M...; Mouna Khecharem; Serge Klosowski; Franck Labbe; Adeline Lacazette; Fabrice Lapeyre; Jérôme Larche; Peggy Larroude; Anne Le Pourhiennec; Nolwenn Le Sache; Sylvie Ledru; Annick Lefebvre; Clément Legeay; Florence Lemann; Claire Lesteven; Marion Levast-Raffin; David Leyssene; Isabelle Ligi; Alain Lozniewski; Pierre Lureau; Franck-Olivier Ma...; Edith Malpote; Stéphane Marret; Pascale Martres; Guillaume Menard; Laura Menvielle; Laurent Mereghetti; Véronique Merle; Pascale Minery; Virginie Morange; Julien Mourdie; Anaelle Muggeo; Jean Nakhleh; Marie-Noëlle Noulard; Claude Olive; Hugues Patural; Pascale Penn; Manuel Petitfrere; Bruno Pozetto; Brigitte Riviere; Audrey Robine; Christine Roques ...; Raymond Ruimy; Amine Siali; Stéphanie Soive; Souad Slimani; Anne-Sophie Trent...; Dominique Trivier; Christian Vandenb...; Laurent Villeneuve; Evelyne Werner; Stéphane Le Vu; Nathalie Van Der ...
• Keywords: Male; 0301 basic medicine; Bloodstream catheter-related infection; Preterm babies; 610; NRCS-A clone; Staphylococcus capitis; 03 medical and health sciences; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Drug Resistance, Multiple, Bacterial; Intensive Care Units, Neonatal; Sepsis; 616; [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]; Humans; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases; [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases; Neonatal Intensive Care Unit (NICU); Brief Report; Infant, Newborn; Neonates; Staphylococcal Infections; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system; Anti-Bacterial Agents; 3. Good health; Nationwide active surveillance; Catheter-Related Infections; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Female; France; [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; Infant, Premature

AbstractTo increase the knowledge about S. capitis in the neonatal setting, we conducted a nationwide 3-month survey in 38 neonatal intensive care units (NICUs) covering 56.6% of French NICU beds. We demonstrated 14.2% of S. capitis BSI (S.capBSI) among nosocomial BSIs. S.capBSI incidence rate was 0.59 per 1000 patient-days. A total of 55.0% of the S.capBSIs were late onset catheter-related BSIs. The S. capitis strains infected preterm babies (median gestational age 26 weeks, median birth weight 855 g). They were resistant to methicillin and aminoglycosides and belonged to the NRCS-A clone. Evolution was favorable in all but one case, following vancomycin treatment.