Risk factors for infection after carbapenem-resistant Acinetobacter baumannii colonization

• DOI: 10.1007/s10096-024-04936-2
• Publication Date: 2024-09-16T16:02:33Z
• Authors: Maddalena Peghin; Filippo Givone; Maria de Martino; Raja Waqar Ali; Elena Graziano; Miriam Isola; Paolo Antonio Grossi
• Keywords: Acinetobacter baumannii; Medical microbiology; Carbapenem

Abstract Purpose Predicting infection risk in carbapenem-resistant Acinetobacter baumannii (CRAB) colonized patients may help improving timely appropriate antibiotic therapy. This study aims to explore factors for developing infections hospitalized with previous CRAB colonization. Methods We performed an observational retrospective cohort at ASST Sette Laghi-Varese Hospital between January 2020 and December 2022. All consecutive adult (> 18 years old) documented colonization by any anatomical site or preceded were included. Univariate multivariate analyses investigate factors. Results Overall, 144 included the study: 104 only 40 infected patients. Colonization rates significantly changed over (2020–2022, p < 0.001). The incidence of carriers was 27.8% (40/144). Median time from 4 days (IQR 1-8.5). inhospital mortality 32.7% 55.0% patients, respectively. At multivariable logistic regression cardiovascular disease (OR 5.83, 95% CI 1.12–30.43, = 0.037), COVID-19 3.72, 1.16–11.91, 0.027) intensive care unit (ICU) admission 8.83, 2.94–26.51, 0.001) independently associated after Conclusions observed increased disease, admitted ICU setting. Additional evidence is needed identify predictors