Effect of preoperative chemotherapy on the histopathological classification of gastric cancer

• DOI: 10.1007/s10120-023-01442-w
• Publication Date: 2023-11-10T14:02:21Z
• Authors: I. A. Caspers; H. D. Biesma; K. Wiklund; F. Pontén; P. Lind; M. Nordsmark; K. Sikorska; E. Meershoek-Klei...; H. H. Hartgrink; C. J. H. van de V...; J. W. van Sandick; M. Verheij; A. Cats; N. C. T. van Grieken
• Keywords: Concordance; Surgical oncology; Histology

Abstract Background In the era of individualized gastric cancer (GC) treatment, accurate determination histological subtype becomes increasingly relevant. As yet, it is unclear whether preoperative chemotherapy may affect subtype. The aim this study was to assess concordance in between pretreatment biopsies and surgical resection specimens before after introduction perioperative treatment. Methods Histological centrally determined paired GC patients treated with either surgery alone (SA) Dutch D1/D2 or (CT) CRITICS trial. as specimen considered gold standard. Concordance rates sensitivity specificity intestinal, diffuse, mixed, “other” subtypes were analyzed. Results total, 105 515 pairs SA CT cohorts, respectively, included. Overall 72% 74% cohort substantially higher diffuse (83% 86%) compared intestinal (70% 74%), mixed (21% 33%) (54% 54%). cohort, sensitivities specificities 0.88 0.71 0.67 0.93 0.20 0.98 0.50 subtypes, respectively. Conclusion Our results suggest that on suboptimal but impact negligible.