Skeletal muscle specific genes networks in cattle

• DOI: 10.1007/s10142-010-0175-2
• Publication Date: 2010-06-03T09:22:40Z
• Authors: Natalia Moreno-Sá...; Julia Rueda; María J. Carabaño; Antonio Reverter; Sean McWilliam; Carmen González; Clara Díaz
• Keywords: Gene regulatory network

While physiological differences across skeletal muscles have been described, the differential gene expression underlying them and discovery of how they interact to perform specific biological processes are largely be elucidated. The purpose present study was, firstly, profile by cDNA microarrays between two muscle types, Psoas major (PM) Flexor digitorum (FD), in beef cattle then interpret results context a bovine coexpression network, detecting possible changes connectivity system. Eighty four genes were differentially expressed (DE) muscles. Approximately 54% encoded metabolic enzymes structural-contractile proteins. DE involved similar functions, but proportion each category varied within muscle. A correlation matrix was obtained for 61 out 84 from network. Different groups observed, largest one having 28 contractile genes, up-regulated PM, mainly encoding fast-glycolytic fibre structural components glycolytic enzymes. In FD, related cell support seemed constitute its identity feature did not positively correlate rest FD. Moreover, some observed different ontologies. Our confirm existence dependent transcription pattern suggest necessity integrating types comprehensive networks transcriptional landscape