LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma

• DOI: 10.1007/s10142-024-01292-4
• Publication Date: 2024-02-14T09:02:21Z
• Authors: Dong Jin; Yongfeng Hui; Di Liu; Nan Li; Junzhi Leng; Genwang Wang; Qi Wang; Zhenhui Lu
• Keywords: Immunosuppression

Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor with high recurrence rate and poor prognosis. Long intergenic nonprotein coding RNA 942 (LINC00942) reported to be related ferroptosis the immune response in HCC serves as an oncogene various cancers. This research aimed explore contribution of LINC00942 progression. Functional assays were used evaluate functional role vitro vivo. Mechanistic conducted assess association insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) solute carrier family 7 member 11 (SLC7A11) regulatory pattern cells. was found exhibit upregulation tissue facilitated cell proliferation, suppressed ferroptosis, converted naive CD4 + T cells inducible Treg (iTreg) by regulating SLC7A11. Furthermore, SLC7A11 expression positively modulated IGF2BP3 shared RNA-binding (RBP) for The between 3′ untranslated region verified, recruit promote stability m6A-dependent manner. Moreover, mouse proliferation inhibited, number FOXP3 CD25 increased, while enhanced after knockdown suppresses induces immunosuppression recruiting enhance stability, which may provide novel therapeutic targets HCC.