TFAP2A-regulated CRNDE enhances colon cancer progression and chemoresistance via RIPK3 interaction

• DOI: 10.1007/s10142-025-01545-w
• Publication Date: 2025-02-15T04:48:01Z
• Authors: Xin Gao; Yanming Huang; Tonghui Wei; Jingmin Xue; Filippov Iurii; Laishou Yang; Liying Wang; Hao Li; Genshen Mo; Yuze Huang; Haonan Xie; Hang Wang; Shenghan Lou; Peng Han
• Keywords: Pyroptosis

Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain unclear. In this study, we identified CRNDE highly CC, contributing tumor progression Mechanically, regulated by transcription factor TFAP2A. Additionally, inhibits pyroptosis, form programmed cell death, promoting ubiquitin-mediated degradation RIPK3, thereby reducing sensitivity cells 5-fluorouracil (5-FU). Our findings suggest that TFAP2A/CRNDE/RIPK3 axis plays critical colon chemoresistance, highlighting therapeutic targets improving outcomes.