Periodontitis and gingival bleeding associate with intracranial aneurysms and risk of aneurysmal subarachnoid hemorrhage

• DOI: 10.1007/s10143-019-01097-1
• Publication Date: 2019-04-10T19:41:16Z
• Authors: Joona Hallikainen; Antti Lindgren; Jarno Savolainen; Tuomas Selander; Antti Jula; Matti Närhi; Timo Koivisto; Jari Kellokoski; Pekka Ylöstalo; Anna Liisa Suominen; Juhana Frösen
• Keywords: Bleeding on probing

Oral bacteria DNA has been found in intracranial aneurysms (IA) and a high prevalence of periodontitis was reported IA patients. We investigated whether associates with formation aneurysmal subarachnoid hemorrhage (aSAH). First, we compared case-control setting the periodontal disease patients (42 unruptured IA, 34 ruptured IA) age- gender-matched controls (n = 70) from same geographical area (Health 2000 Survey, BRIF8901). Next, at baseline associated aSAH 13-year follow-up study 5170 Health Survey participants. Follow-up data obtained national hospital discharge cause death registries. Univariate analysis, logistic regression, Cox-regression were used. Periodontitis (≥ 4mm gingival pocket) severe 6mm 92% 49% respectively IAs (OR 5.3, 95%CI 1.1-25.9, p < 0.000 OR 6.3, 1.3-31.4, 0.001, respectively). Gingival bleeding had an even stronger association, especially if detected 4-6 teeth sextants 34.4, 4.2-281.3). Severe ≥ 3 or increased risk during (HR 22.5, 3.6-139.5, 0.001 HR 8.3, 1.5-46.1, 0.015, Association development independent gender, smoking status, hypertension, alcohol abuse. associate for eventual aSAH. Further epidemiological mechanistic studies are indicated.